The hub genes

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August undefined, 2024

WebApr 9, 2024 · The hub genes in this network suggest intracellular interactions and complex functions. Yuanshuai Zhou, Yongjing Liu, Kening Li, Rui Zhang, Fujun Qiu, Ning Zhao, Yan … WebThen we applied CytoHubba to calculate the degree of each protein node. The results demonstrated that the top 10 genes ranked by the node degree were IL6, MMP3, INHBA, …

Identification of Hub Genes in Type 2 Diabetes Mellitus Using ...

WebMay 27, 2024 · The hub genes were identified by using the cytoHubba plug-in of Cytoscape. Here, we used seven common algorithms (MCC, MNC, Degree, Closeness, Radiality, Stress, EPC) to evaluate and select hub genes. Webtic strategy in RA due to a lack of systematic studies on validated biomarkers. The present study aimed to identify hub pyroptosis biomarkers and immune infiltration in RA. The gene expression profiles of synovial tissues were obtained from the Gene Expression Omnibus (GEO) database to identify differentially expressed pyroptosis genes (DEPGs). Meanwhile, … food lion in richlands

Seven key hub genes identified by gene co-expression network in ...

WebMay 20, 2024 · Despite the genes and pathways associated with NP development we found, 8 hub genes (C3, C1qb, Ccl2, Cxcl13, Timp1, Fcgr2b, Gal, Lyz2) that were responsible for NP development regulation were identified and some of them have been reported to present an intimate correlation with NP development. WebFeb 22, 2024 · The hub genes were derived from the combined results of a protein–protein interaction (PPI) network and weighted gene coexpression network analysis (WGCNA). The receiver operating characteristic (ROC) curves of hub genes were plotted to evaluate their clinical diagnostic value. WebFeb 7, 2024 · Data mining the Oncomine database validated that the hub genes have a significant high level of expression in HCC samples compared normal samples (t-test, p < 0.05). Survival analysis indicated that overexpression of the hub genes is associated with a significant reduction (p < 0.05) in survival time in HCC patients. elderwood at williamsville assisted living

Frontiers Analysis of Hub Genes and the Mechanism of Immune ...

Frontiers Identification of Hub Genes and Key Pathways …

WebMar 17, 2024 · The 31 cuproptosis-related genes (CRGs) were obtained from previous published studies. The differentially expressed genes (DEGs) and Weighed gene co … WebAug 11, 2024 · In summary, through WGCNA, we identified 11 hub genes, which might serve as potential diagnostic and/or therapeutic biomarkers for gastric cancer. Profile data … elderwood at williamsville bassett roadWebFurthermore, we identified 11 hub genes, MCM3, TRMT6, AURKA, CDC20, TOP2A, ECT2, TK1, MCM2, FEN1, NCAPD2 and KPNA2 which played key roles in HCC. The results of … elderwood at wheatfield niagara falls ny

"WebJan 27, 2024 · The RNASEL, MAPK4, SPI1, MYBL2, and MYBL1 genes were determined as hubs in the BP vs. AP network. In the P vs. AP network, the HSPA8, ND5, ABCA2, GATA1, and CYTB genes were the top five hub... " - The hub genes

The hub genes

Identification of Hub Genes and Immune Cell Infiltration ...

WebNov 21, 2024 · (a–d) shows that the unique hub genes selected with WGCNA, and (e–h) are the unique hub genes selected with random forest. The overexpression of all the unique hub genes was significantly ... WebMar 13, 2024 · The team show that hub genes are conserved in other organisms and suggest that their normal function is to act as genetic buffers, minimizing the effects of mutations in other genes. Further development of genetic interaction maps should help to …

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WebJun 6, 2024 · Core genes are the markers for the processes involved in a specific biological response, and hub genes usually play an essential role in gene regulation networks . … WebApr 12, 2024 · We built a network of PPI using String, after which hub genes were identified using Cytohubba and MCODE. Cytohubba determined the top 10 genes based on node …

WebThe survival analysis showed 4 highly expressed hub genes COL4A1, SDC1, CDKN2A, and TOP2A which correlated with overall survival in ovarian cancer patients. Moreover, the expression of the 4 hub genes was validated by the GEPIA database and the Human Protein Atlas. Conclusion. WebOf the 4 hub genes significantly correlated with OS in AML, SUSD3 is a cell-surface protein with unknown function that may be involved in the growth and development of breast cancer via the estrogen receptor pathway. Some evidence indicates that the gene acts downstream of the estrogen receptor and that estrogen enhances its expression.

WebThese hub genes are accumulated on cell cycle and drug catabolism, which may be latent targets for HCC, and supply further strategies for clinical diagnosis, accurate treatment and prognosis analysis. Ethics Statement. This study was approved by the Institutional Review Board of Beijing Ditan Hospital (2024-044-001). WebDarst, B. F., Dadaev, T., Saunders, E., Sheng, X., Wan, P., Pooler, L., … Haiman, C. A. (2024). Germline sequencing DNA repair genes in 5,545 men with aggressive ...

WebMay 24, 2024 · However, the signaling pathways and driver genes involved in these disparate subtypes are ambiguous. This study integrated three cohort profile datasets, …

WebAug 1, 2024 · Thereafter, the 94 genes were subjected to PPI analysis to find the genes much more associated with NP and a functional module composed of 48 genes were … food lion in pt wentworthWebAug 8, 2024 · Functional enrichment analysis indicated that the genes were principally involved in immune system regulation, host defense, and negative regulation of apoptosis … food lion in reidsvilleWebJan 19, 2024 · Gene ID: 128266840, updated on 19-Jan-2024 Gene type: ncRNA Also known as: lncFAM. Go to complete Gene record for MYREM; Go to Variation Viewer for MYREM variants; Genomic context. Location: 19q13.33. Variation. Resource Links for this gene; SNP: food lion in roanoke vaWebThen we applied CytoHubba to calculate the degree of each protein node. The results demonstrated that the top 10 genes ranked by the node degree were IL6, MMP3, INHBA, MMP1, VCAN, FGF7, PDGFRA, THBS2, IL11, and CYR61, respectively ( Figure 3) ( Table 4 ). Table 4 Function and Connectivity of the Ten Hub Genes. elderwood at williamsville nyWebJul 23, 2024 · Hub genes are a class of highly connected genes within a module and are significantly associated with biological function [ 18 ]. In this study, we defined genes with high module membership (MM) ( cor.weighted > 0.8) as hub genes. We considered hub genes present in both GSE45216–98774 and GSE108008 as validated hub genes. elderwood brockport uniformWebJan 19, 2024 · Twenty-two hub genes were upregulated in COVID-19 and IPF, for which 155 candidate drugs were predicted (adj.P.value < 0.01). Conclusion. Identifying the hub genes aberrantly regulated in both COVID-19 and IPF may enable development of molecules, encoded by those genes, as therapeutic targets for preventing IPF progression and SARS … food lion in robersonvilleWebLu, P.-L., Chen, N.-Z., An, R., Su, Z., Qi, B.-S., Ren, F., … Wang, X.-C. (2006). A novel drought-inducible gene, ATAF1, encodes a NAC family protein that ... food lion in robersonville nc