WebNOACs (Novel Oral Anticoagulants) or DOACs (Direct Oral Anticoagulants) Currently there are four NOAC/DOACs available in the UK; Rivaroxaban. Apixaban. Edoxaban. Dabigatran. The decision regarding which will be most appropriate can be made by your GP, local anticoagulation clinic or PH specialist centre. WebPatients with renal impairment require dose adjustments for direct oral anticoagulants (DOACs), though there is uncertainty regarding their use in severe chronic kidney disease. Inappropriately dosed DOACs may increase risk of ischemic events when under-dosed, or risk of bleeding when over-dosed.
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