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Klf4 and mitophagy

WebFeb 19, 2024 · It is well-known that atherogenesis is a complex multi-component process that includes lipid metabolism disorders, inflammation, oxidative stress, autophagy disorders and mitochondrial dysfunction. Autophagy is a cellular control mechanism that is critical to maintaining health and survival. WebMar 9, 2024 · Mitophagy, a special form of autophagy occurring in the mitochondrion, is a crucial process that can selectively remove superfluous or dysfunctional mitochondria, to maintain mitochondrial quality and function [ 34 ].

Key protein drives

WebJan 1, 2024 · The expression of some transcription factors, such as Yamanaka factors (OSKM), including Oct3/4, Sox2, c-Myc, and Klf4, reprograms somatic cells to induced pluripotent stem cells (iPSCs). 72 This... WebAug 4, 2015 · The initial hint that KLF4 regulates mitochondrial biology came from genome-wide studies that revealed a strong signature for KLF4's control of mitochondrial genes. Next, Liao and his... gettysburg times obituaries today https://integrative-living.com

Key protein drives

WebApr 7, 2024 · Krüppel-like factor 4 (KLF4), a context-dependent transcription factor that can act as both a tumor suppressor and an oncogene, is involved in many molecular pathways that respond to low glucose and increased reactive oxygen species (ROS), raising the question of its role in metabolic stress as a result of increased proliferation of tumor cells. WebJan 1, 2024 · We found that KLF4 plays an integral role in the ability of cells to recover from mitochondrial damage. We demonstrated that one mechanism through which KLF4 performs this function is by promoting the transcription of Bnip3, a protein which targets autophagosomes to damaged mitochondria, facilitating mitophagy. WebMitophagy plays an important role in maintaining mitochondria ... Sox2, Klf4 and c-Myc, is sufficient to reverse-differentiate fibroblasts into pluripotent stem cells (22). Interestingly, recent ... gettysburg to chambersburg pa

Krüppel-like factor 4 (KLF4) induces mitochondrial fusion …

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Klf4 and mitophagy

Cells deficient for Krüppel-like factor 4 exhibit …

WebNov 24, 2014 · KLF4 deficiency in mouse bone marrow drastically reduced lung metastasis that was accompanied by decreased recruitment of CCR2 + MDSCs in the lung. (a) Six … WebDownload scientific diagram Addition of Bnip3 to Klf4-null cells rescues defects in mitophagy. (A) MEFs were transfected with either GFP control or Bnip3-myc, treated with BafA for 12 h, and ...

Klf4 and mitophagy

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WebJan 1, 2024 · In this study, we sought to identify a mechanistic connection between KLF4 and mitophagy. Using flow cytometry, we found that Klf4 -null MEFs have diminished … WebApr 12, 2024 · Download Citation Transcriptional regulation of autophagy and its implications in human disease Macroautophagy/autophagy is a conserved catabolic pathway that is vital for maintaining cell ...

WebAug 4, 2015 · From there, the researchers showed that KLF4 also regulates mitochondrial biogenesis (production of new mitochondria) and mitophagy (mitochondrial repair and maintenance). WebApr 25, 2024 · Treatment of smooth muscle cells with porcine pancreatic elastase or interleukin (IL)-1 β activated autophagy-related genes in vitro while treatment with a siRNA to Kruppel-like transcription factor 4 ( Klf4 ), Kruppel-like transcription factor 2 ( Klf2) or Zinc-finger protein 148 ( Zfp148) separately inhibited activation of autophagy genes.

WebMar 22, 2024 · Mitophagy is a form of macroautophagy that selectively degrades damaged mitochondria. Double-membraned autophagosomes enclose whole mitochondria, or selectively target the damaged areas ... WebKLF4-expressing cells portrayed evidence of extensive mitochondrial fusion that may explain the delayed cell death. Mechanistically, KLF4 did not directly regulate the three …

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WebJan 9, 2024 · Conclusion: ATPIF1 maintains the normal structure of mitochondria, inhibiting the activation of mitophagy and other signaling pathway in endothelial cells. Loss of … christophe robin hair detox ritualWeb北京万方数据股份有限公司. 万方数据电子出版社. 京ICP证010071号. 京公网安备11010802024237号. 京ICP备08100800号-1. 违法和不良信息举报电话：4000-115-888，举报邮箱：[email protected]，举报专区 gettysburg to harpers ferry wvWebDec 1, 2024 · Our findings suggest that in Klf4-null cells, decreased Bnip3 expression impairs mitophagy and is associated with increased mitochondrial ROS production after … gettysburg to philly distanceWebTNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1. christophe robin hair products nzWebAug 4, 2015 · KLF4 serves as a critical transcriptional regulator of mitochondrial homeostasis in the heart through (i) cooperation with the ERR/PGC-1 transcriptional … christophe robin hair products reviewsWebMitophagy serves as a key cellular quality control mechanism involving sequestration of damaged mitochondria within autophagosomes and their subsequent degradation in lysosomes. However, it remains largely unknown whether mitophagy is involved in the regulation of energy metabolism in neurons, and if so, whether metabolic deficiency in AD … christophe robin melting hair maskWebHere, using human glioblastoma cells, we investigated KLF4’s effects on cancer cell metabolism. We found that forced KLF4 expression promotes mitochondrial fusion and … christophe robin oh my cream